ABSTRACT
Fibromyalgia Syndrome (FM) is a condition characterized by generalized and chronic muscle pain, with no evidence of inflammation and accompanied by other symptoms such as tiredness, anxiety and depression. However, little is discussed about the oral manifestations associated with this syndrome. The present study aimed to analyze the oral changes found in patients diagnosed with FM and to relate them to the disease. The sample consisted of 67 participants diagnosed with fibromyalgia and who agreed to participate in the research by signing the informed consent form. Patients were assessed through examination and a questionnaire interview. The results obtained showed that the drugs most used by the participants were antidepressants, analgesic medications and anticonvulsants, 58.2% of the participants rated their own oral hygiene as good, 70.1% of the participants said they made regular visits to the dentist, 92.4% reinforced that pain makes it impossible to perform daily tasks, but only 47.0% believed that pain interferes with the quality of oral hygiene, 55.2% of the participants stated they had restorations or caries, 34.3% had no dental units, 20.9% have some type of prosthesis, 74.2% reported xerostomia. It is concluded that patients with FM have a high prevalence of xerostomia and that there is a strong lack of information on the risk factors correlated with FM, as well as on the oral manifestations caused by the syndrome, strengthening the need for the patient's monitoring and guidance of dental surgeon in conjunction with a multidisciplinary team. (AU)
A Síndrome de Fibromialgia (FM) é uma condição caracterizada por dor muscular generalizada e crônica, sem evidência de inflamação e acompanhada de outros sintomas como cansaço, ansiedade e depressão. Entretanto, pouco se discute sobre as manifestações bucais associadas a esta síndrome, diante disto, o presente estudo objetivou analisar as alterações bucais encontradas em pacientes com o diagnóstico de FM e relacioná-las à doença. A amostra foi constituída de 67 participantes com diagnóstico de fibromialgia e que aceitaram participar da pesquisa mediante a assinatura do termo de consentimento livre esclarecido. Os pacientes foram submetidos a um exame clínico e a uma entrevista por questionário. Os resultados obtidos mostraram que os fármacos mais utilizados pelos participantes foram antidepressivos, medicamentos para analgesia e anticonvulsivantes, 58,2% dos participantes avaliaram sua própria higiene oral como boa, 70,1% dos participantes afirmaram fazer visitas regulares ao dentista, 92,4% reforçaram que as dores impossibilitam de realizar tarefas cotidianas, mas somente 47,0% acreditam que as dores interferem na qualidade da higiene oral, 55,2% dos participantes afirmou possuir restaurações ou cárie, 34,3% possuir ausência de elementos dentais, 20,9% possuir algum tipo de prótese, 74,2% relatou xerostomia. Conclui-se que pacientes com FM possuem alta prevalência de xerostomia e que há uma forte falta de informação sobre os fatores de risco correlacionados à FM, bem como sobre as manifestações bucais provocadas pela síndrome, fortalecendo a necessidade do acompanhamento e da orientação do cirurgião-dentista em conjunto com a equipe multiprofissional. (AU)
ABSTRACT
ABSTRACT Objective To investigate the histological influence of waterpipe smoke exposure on lung tissues of Swiss mice during the periods of 7, 15, 30, 60, and 90 days. Methods The sample consisted of 60 animals, divided into 6 groups, one control group, exposed only to air, and the other experimental groups, daily submitted to water pipe smoke for 30 minutes through the whole body system, for 7, 15, 30, 60 and 90 days. After these periods, the mice were euthanized to obtain the tissue samples and subsequent preparation and analysis of histological slides. Results In the slide microscopy, the control group presented normal aspects. In experimental groups, exacerbation of inflammation was observed, there was a increased thickness of intra-alveolar septa, reduced alveolar lumen, areas of ciliary loss, and neovascular formation. And as the animals' exposure to smoke was extended, the progressive exacerbation of these pulmonary changes was noted. Conclusions The exposure to waterpipe smoke stimulates inflammation and cellular changes in lung tissues of Swiss mice and suggests that the longer the animals' exposure period, the more exacerbated this picture will appear.